![]() 1Įxpression PV and MF: Mechanism of disease 10. The signaling of cytokines and growth factors important for hematopoiesis and immune function. Jakafi, a kinase inhibitor, inhibits JAK1 and JAK2 (Janus-associated kinases 1 and 2), which mediate.Please see Important Safety Information on the backĬover and accompanying Full Prescribing Information. Post–polycythemia vera myelofibrosis and post–essential Or high-risk myelofibrosis, including primar y myelofibrosis, Jakafi is indicated for treatment of patients with intermediate Polycy themia vera who have had an inadequate response ![]() Jakafi is indicated for treatment of patients with Understanding how Jakafi ® (ruxolitinib) inhibits * overactive JAK pathway signaling Warning: Popup annotation has a missing or invalid parent annotation.
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